最終更新日: 2026年5月18日
TRUS (Transrectal Ultrasound-Guided) prostate biopsy was first introduced in 1989 and remains the gold standard for confirming prostate cancer diagnosis, with over 4 million procedures performed worldwide annually. This article covers the possible complications following TRUS prostate biopsy so patients are prepared and know when to seek urgent care.
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Possible complications after TRUS prostate biopsy
- Bleeding complications — typically resolve within 10 days post-procedure:
- Blood in urine (hematuria) — 66%
- Blood in ejaculation (hematospermia) — 38%
- Blood in stool (rectal bleeding) — 28%
- Infectious complications:
- Urinary tract infection — 6%
- Fever — 4%
- Persistent painful urination — 3%
- Pain or burning on urination — 1%
- Serious bloodstream infection (sepsis) — 0.5%
- Serious perineal skin infection — 0.05%
- Other complications:
- Vasovagal response (sweating, nausea, dizziness, fainting) — 7%
- Acute urinary retention — 0.3%
- Myocardial infarction — 0.3%

The infection risk from TRUS biopsy relates to its transrectal approach — the ultrasound probe necessarily passes through the rectal canal, which is contaminated with bowel flora. Published data confirms that postoperative infection rates cannot be fully eliminated by any preoperative rectal preparation protocol, even with proper prophylactic antibiotics given before every procedure.

Despite these complications, the benefits of TRUS biopsy in correctly confirming prostate cancer diagnosis outweigh the risks when appropriate patient selection is applied. Under specialist urological care, careful patient selection and pre-procedure preparation minimize risks. Informed counseling about potential complications reduces patient anxiety and helps patients recognize warning signs that require urgent medical attention.
Frequently Asked Questions About Post-TRUS Prostate Biopsy Care
Is it normal to see blood in urine, semen, or stool after prostate biopsy?
Yes. Bleeding complications are very common after TRUS prostate biopsy. Blood in urine (hematuria) occurs in up to 66% of patients, blood in ejaculation (hematospermia) in 38%, and rectal bleeding in 28%. These are expected side effects of the needle passes through the prostate and surrounding tissue. In the vast majority of cases, all bleeding resolves spontaneously within 10 days. No special treatment is required unless bleeding is severe or prolonged beyond this period.
What signs of infection should I watch for after prostate biopsy?
Fever above 38°C, shaking chills, worsening pain, difficulty urinating, or feeling generally unwell after TRUS biopsy are warning signs that require immediate medical attention. These may indicate urinary tract infection (6%), sepsis (0.5%), or perineal infection (0.05%). The infection risk is inherent to the transrectal approach — the probe passes through the rectum, which contains bowel bacteria. Prophylactic antibiotics are given before every TRUS biopsy to reduce this risk, but cannot eliminate it entirely. Seek emergency care if you develop high fever or chills after the procedure.
Why is TRUS biopsy still performed if it carries infection risk?
TRUS-guided biopsy remains the definitive method for confirming prostate cancer diagnosis. More than 4 million procedures are performed worldwide annually. The diagnostic benefit — definitively confirming or ruling out prostate cancer — outweighs the complication risk in appropriately selected patients. Modern advances include MRI-fusion-guided biopsy and transperineal biopsy (which avoids the rectal route entirely, significantly reducing infection risk). Dr. Soarawee Weerasopone offers the latest MRI-fusion transperineal approach at Bangkok Hospital Headquarters.
If you have concerns about prostate biopsy or have developed complications after the procedure, Dr. Soarawee Weerasopone offers specialist consultations at Bangkok Hospital Headquarters. 診療をご予約.
**免責事項:** このコンテンツは、バンコク病院本部の認定泌尿器科医であるSoarawee Weerasopone博士によって作成およびレビューされました。教育目的のみのものであり、医学的アドバイスを構成するものではありません。いかなる医療処置を開始する前にも、必ず資格のある医療専門家にご相談ください。.
医学的に記述・監修: ソアラウィー・ウィーラソポーン医師(ポム医師) — バンコク病院本社 泌尿器科専門医。 国際フェロー:ベイラー医科大学(米国)、順天堂大学(日本)、長庚紀念医院(台湾)。.

ソアラウィー・ウィーラソポーン医師(ポム医師)は、バンコク病院本院の泌尿器科専門医で、男性医学、ロボット手術(ダヴィンチシステム)、腎結石治療を専門としています。ベイラー医科大学(米国)、順天堂大学医学部附属順天堂医院(日本)、長庚記念医院(台湾)での国際フェローシップを修了しています。このサイトのすべての医療コンテンツは、ソアラウィー医師の臨床経験と国際的なトレーニングに基づいて、同医師によって作成・監修されています。.

