อาหารและมะเร็งต่อมลูกหมาก: สิ่งที่หลักฐานสนับสนุนอย่างแท้จริง

อัปเดตล่าสุด: 15 สิงหาคม 2569

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Diet is one of the subjects my patients most enjoy discussing — partly because, unlike age and family history, it is something they can actually act on. Here is an updated look at the evidence, sorted honestly by how strong that evidence actually is.

One thing to set expectations first. Almost all of this evidence comes from observational studies — they show that populations eating certain foods develop less prostate cancer, which is not the same as proving the food is the reason. Diet shifts the odds modestly; it does not confer immunity, and it is not a substitute for PSA screening and a urology review at the appropriate age. Eat well by all means — but do not let a good diet talk you out of getting checked.

Strongest evidence

1. Tomatoes — lycopene, the antioxidant that gives tomatoes their colour, is associated with a reduced risk of prostate cancer, with a dose-related effect reported from around 2 mg daily taken consistently. The proposed mechanism is that lycopene reduces the expression of genes involved in testosterone metabolism, and testosterone is central to how prostate cancer behaves. Worth knowing: lycopene is absorbed better from cooked and processed tomatoes than from raw ones, so tomato sauce is not the inferior option here.
2. ชาเขียว — catechins, the antioxidants concentrated in green tea, show inhibitory effects on cancer progression. The most-cited work comes from Japan, where green tea consumption is among the highest in the world, and suggests that five or more cups a day is associated with lower prostate cancer risk.

Strongest here is a relative term, and it is worth being precise about what it means. Even for tomatoes and green tea, the evidence is consistent observational data plus a plausible laboratory mechanism — not randomised trials showing that adding either one to your diet lowers your own risk. It is enough to justify a sensible eating pattern. It is not enough to treat any food as treatment.

Promising, but not established

3. Fish and vegetable oils — unsaturated fatty acids may help reduce risk, though the evidence is thinner. What is better established is the other side of the coin: a high-fat diet is linked to several cancers including prostate cancer, and animal studies show high-fat feeding significantly increases tumour size. So the safer conclusion is less about adding fish oil and more about displacing saturated fat.
4. Legumes and soy — isoflavones are abundant in legumes and structurally resemble oestrogen, so they can bind oestrogen receptors in prostate tissue and may inhibit cancer cell growth. The mechanism is plausible and the population data are encouraging, but this has not been proven in humans.

Still uncertain

5. The “prudent” dietary pattern — broadly, a diet rich in vegetables, fruit, fish and legumes. Whether the pattern as a whole protects against prostate cancer remains unsettled. What the data do show reasonably clearly is the reverse: high consumption of red meat, processed meat, potatoes and high-fat dairy is associated with increased prostate cancer risk.

If you take one practical message from all this, let it be that the evidence for avoiding certain foods is stronger and more consistent than the evidence for any single protective food. Cutting back on red and processed meat and high-fat dairy is a better-supported move than loading up on any one superfood — and it is worth doing alongside screening, not instead of it.

One more caution, aimed at anyone already diagnosed. Nothing on this page is a treatment for prostate cancer. Diet is discussed here as a question of risk in men who do not have the disease; if you have been diagnosed, no food or supplement substitutes for the treatment plan agreed with your urologist and oncologist, and choices such as high-dose supplements should be raised with them before you start.

สำหรับการตรวจคัดกรองมะเร็งต่อมลูกหมาก การประเมินค่า PSA หรือคำแนะนำด้านโภชนาการและการใช้ชีวิตประจำวันแบบเฉพาะบุคคล นายแพทย์สรวีย์ วีระโสภณ ให้คำปรึกษาเฉพาะทางที่โรงพยาบาลกรุงเทพ สำนักงานใหญ่. นัดหมายปรึกษาแพทย์. นัดหมายที่โรงพยาบาลสมิติเวช ศรีราชา ได้โดยโทรติดต่อแผนกทางเดินปัสสาวะที่ 088-022-1445.

Bangkok Hospital also runs a Telemedicine service, which works well for a conversation like this one — reviewing PSA results, deciding when screening should start given your family history, or going through diet and lifestyle. Arrange it in advance by email to the Urology department at bhquro@bdms.co.th. สมิติเวช ศรีราชา มีเฉพาะแบบพบหน้าเท่านั้น.

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ข้อจำกัดความรับผิดชอบ This content is written and reviewed by Dr. Soarawee Weerasopone, a board-certified urologist at Bangkok Hospital Headquarters. It is intended for educational purposes only and does not constitute medical advice. Dietary measures may influence risk but do not prevent prostate cancer and are not a substitute for appropriate screening or, in men already diagnosed, for treatment. No medical advice, diagnosis or prescription is provided through personal messaging channels. Always consult a qualified healthcare professional before starting any medical treatment.