Varicocele Oral Treatment with MPFF

Q: Can varicocele be treated without surgery?

Yes, for symptomatic varicocele. MPFF (Micronized Purified Flavonoid Fraction) provided complete relief from testicular discomfort in 87.5% and improvement in 12.5% of patients after 6 months. Surgical varicocelectomy remains the primary treatment especially for fertility.

Q: Does MPFF improve fertility in varicocele patients?

MPFF significantly improves sperm motility after 6 months but does not improve semen volume, concentration, or morphology. For fertility goals, surgical varicocelectomy is more effective as it directly corrects venous backflow and testicular temperature elevation.

បានធ្វើបច្ចុប្បន្នភាពចុងក្រោយ៖ ខែឧសភា 18, 2026

Soaravy Weerasopone, ឯកទេសប្រព័ន្ធទឹកនោម

ជ្ឈមណ្ឌលកណ្តាលនៃមន្ទីរពេទ្យបាងកក។

មន្ទីរពេទ្យ Samitivej Sriracha, Chonburi

ទំនាក់ទំនង LINE

As I have previously discussed varicocele disease and its effect on male fertility, most gentlemen who experience this problem ultimately end up with surgical correction. This topic will present an alternative oral medication that may improve symptomatic varicocele treatment.

You can read my Varicocele overview article here.

មជ្ឈមណ្ឌលផ្នែកជម្ងឺប្រព័ន្ធទឹកនោមនៃមន្ទីរពេទ្យបាងកក ប្រទេសថៃ។ កក់លេខរៀងការណាត់ជួបតាម online 02-310-3009 bhquro@bdms.co.th
មន្ទីរពេទ្យ Samitivej Sriracha ខេត្តឈុនបូរី។ 088-022-1445

Varicocele causes infertility and testicular discomfort.

To understand the treatment rationale, we must first understand how varicocele harms fertility. The testicle functions optimally at around 35°C. Varicocele causes venous backflow of blood at core body temperature (37°C) to pool around the testicle, raising testicular temperature and impairing sperm production, leading to infertility and testicular discomfort.

Varicocele pathophysiology is similar to varicose veins of the leg.

From literature review, only one scientifically approved oral medication exists for varicocele — Micronized Purified Flavonoid Fraction (MPFF). MPFF improves venous tone and contractility and decreases venous blood pressure. It is also used by vascular surgeons for varicose veins of the lower extremities.

រោគសញ្ញា varicocele អាចត្រូវបានធ្វើឱ្យប្រសើរឡើងជាមួយនឹងថ្នាំមាត់។

ការព្យាបាល Varicocele៖ យុទ្ធសាស្ត្រថ្នាំតាមមាត់

A clinical trial on MPFF published in 2005 showed the following results after 6 months of treatment:

Testicular discomfort
- 87.5% of patients became completely free from testicular discomfort
- 12.5% experienced significant improvement in testicular discomfort
ភាពគ្មានកូន
- Significantly improved sperm motility
- No significant improvement in semen volume, sperm concentration, or morphology

MPFF may be a useful alternative oral treatment for varicocele-related pain in patients who wish to avoid surgery. However, it appears to have limited effect on improving overall sperm quality. Any questions, you can discuss with your trusted andrologist.

អ្នកអាចចូលមើលគេហទំព័រផ្លូវការរបស់ខ្ញុំ នៅទីនេះ!

Frequently Asked Questions About Varicocele Oral Treatment

Can varicocele be treated without surgery?

Yes, for symptomatic varicocele (pain and discomfort), oral medication with Micronized Purified Flavonoid Fraction (MPFF) has shown clinical benefit. In a clinical trial, 87.5% of patients became completely free from testicular discomfort and 12.5% showed improvement after 6 months of MPFF. However, surgical correction (varicocelectomy) remains the primary and most effective treatment, especially when fertility improvement is the goal.

Does MPFF improve fertility in varicocele patients?

MPFF shows a significant improvement in sperm motility after 6 months of treatment. However, it does not improve semen volume, sperm concentration, or morphology. For patients whose primary concern is fertility rather than pain, surgical varicocelectomy remains the more effective option, as it directly addresses the venous backflow and temperature elevation that impair sperm production.

How does varicocele cause infertility?

The testicle produces healthy sperm at around 35°C, slightly below core body temperature. Varicocele causes abnormal venous backflow of blood at 37°C to pool around the testicle, raising its temperature and impairing spermatogenesis. This leads to reduced sperm quality and male infertility. Correcting the blood flow — either surgically or with venous tone agents like MPFF — is the basis of varicocele treatment.

If you have varicocele and are concerned about pain or fertility, Dr. Soarawee Weerasopone offers specialist consultations at Bangkok Hospital Headquarters. កក់ការពិគ្រោះយោបល់.

ការបដិសេធ៖ ខ្លឹមសារនេះត្រូវបានសរសេរ និងពិនិត្យដោយលោកវេជ្ជបណ្ឌិត Soarawee Weerasopone ដែលជាគ្រូពេទ្យឯកទេសខាងប្រព័ន្ធទឹកនោមដែលមានវិញ្ញាបនបត្រនៅទីស្នាក់ការកណ្តាលមន្ទីរពេទ្យបាងកក។ វាត្រូវបានបម្រុងទុកសម្រាប់គោលបំណងអប់រំតែប៉ុណ្ណោះ ហើយមិនមែនជាដំបូន្មានផ្នែកវេជ្ជសាស្ត្រទេ។ តែងតែពិគ្រោះជាមួយអ្នកជំនាញថែទាំសុខភាពដែលមានសមត្ថភាពមុនពេលចាប់ផ្តើមការព្យាបាលណាមួយឡើយ។.

សរសេរ និងពិនិត្យផ្នែកវេជ្ជសាស្ត្រដោយ៖ វេជ្ជបណ្ឌិត សូរ៉ាវី វីរ៉ាសូផូន (វេជ្ជបណ្ឌិត ប៉ុម) — អ្នកជំនាញខាងប្រព័ន្ធទឹកនោមដែលមានវិញ្ញាបនបត្រពីក្រុមប្រឹក្សាភិបាល ទីស្នាក់ការកណ្តាលមន្ទីរពេទ្យបាងកក។ អ្នកស្រាវជ្រាវអន្តរជាតិ៖ មហាវិទ្យាល័យវេជ្ជសាស្ត្របៃឡ័រ (សហរដ្ឋអាមេរិក) · សាកលវិទ្យាល័យជូនថេនដូ (ជប៉ុន) · មន្ទីរពេទ្យអនុស្សាវរីយ៍ឆាងហ្គុង (តៃវ៉ាន់)។.

វេជ្ជបណ្ឌិត Soarawee Weerasopone

លោកវេជ្ជបណ្ឌិត សូរ៉ាវី វីរ៉ាសូផូន (លោកវេជ្ជបណ្ឌិត ប៉ុម) គឺជាគ្រូពេទ្យឯកទេសខាងប្រព័ន្ធទឹកនោមដែលមានវិញ្ញាបនបត្រនៅទីស្នាក់ការកណ្តាលមន្ទីរពេទ្យបាងកក ដែលមានជំនាញខាងសុខភាពបុរស ការវះកាត់ដោយមនុស្សយន្ត (ប្រព័ន្ធដាវីនស៊ី) និងការព្យាបាលគ្រួសក្នុងតម្រងនោម។ លោកបានបញ្ចប់អាហារូបករណ៍អន្តរជាតិនៅមហាវិទ្យាល័យវេជ្ជសាស្ត្របៃឡ័រ (សហរដ្ឋអាមេរិក) មន្ទីរពេទ្យសាកលវិទ្យាល័យជូនថេនដូ (ជប៉ុន) និងមន្ទីរពេទ្យអនុស្សាវរីយ៍ឆាងហ្គុង (តៃវ៉ាន់)។ ខ្លឹមសារវេជ្ជសាស្ត្រទាំងអស់នៅលើគេហទំព័រនេះត្រូវបានសរសេរ និងពិនិត្យដោយលោកវេជ្ជបណ្ឌិត សូរ៉ាវី ដោយផ្អែកលើបទពិសោធន៍គ្លីនិក និងការបណ្តុះបណ្តាលអន្តរជាតិរបស់លោក។.