정맥류 치료: 경구 약물 역할

마지막 업데이트: 2026년 5월 18일

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As I have previously discussed varicocele disease and its effect on male fertility, most gentlemen who experience this problem ultimately end up with surgical correction. This topic will present an alternative oral medication that may improve symptomatic varicocele treatment.

You can read my Varicocele overview article here.

• 비뇨기과 센터 태국 방콕 병원 온라인 예약 02-310-3009 bhquro@bdms.co.th
• 사미티브 스리라차 병원 촌부리 088-022-1445

To understand the treatment rationale, we must first understand how varicocele harms fertility. The testicle functions optimally at around 35°C. Varicocele causes venous backflow of blood at core body temperature (37°C) to pool around the testicle, raising testicular temperature and impairing sperm production, leading to infertility and testicular discomfort.

From literature review, only one scientifically approved oral medication exists for varicocele — Micronized Purified Flavonoid Fraction (MPFF). MPFF improves venous tone and contractility and decreases venous blood pressure. It is also used by vascular surgeons for varicose veins of the lower extremities.

정맥류 치료: 경구 투약 전략

A clinical trial on MPFF published in 2005 showed the following results after 6 months of treatment:

1. Testicular discomfort
   • 87.5% of patients became completely free from testicular discomfort
   • 12.5% experienced significant improvement in testicular discomfort
2. 불모
   • Significantly improved sperm motility
   • No significant improvement in semen volume, sperm concentration, or morphology

MPFF may be a useful alternative oral treatment for varicocele-related pain in patients who wish to avoid surgery. However, it appears to have limited effect on improving overall sperm quality. Any questions, you can discuss with your trusted andrologist.

내 공식 웹 사이트를 방문 할 수 있습니다 여기!

Frequently Asked Questions About Varicocele Oral Treatment

Can varicocele be treated without surgery?

Yes, for symptomatic varicocele (pain and discomfort), oral medication with Micronized Purified Flavonoid Fraction (MPFF) has shown clinical benefit. In a clinical trial, 87.5% of patients became completely free from testicular discomfort and 12.5% showed improvement after 6 months of MPFF. However, surgical correction (varicocelectomy) remains the primary and most effective treatment, especially when fertility improvement is the goal.

Does MPFF improve fertility in varicocele patients?

MPFF shows a significant improvement in sperm motility after 6 months of treatment. However, it does not improve semen volume, sperm concentration, or morphology. For patients whose primary concern is fertility rather than pain, surgical varicocelectomy remains the more effective option, as it directly addresses the venous backflow and temperature elevation that impair sperm production.

How does varicocele cause infertility?

The testicle produces healthy sperm at around 35°C, slightly below core body temperature. Varicocele causes abnormal venous backflow of blood at 37°C to pool around the testicle, raising its temperature and impairing spermatogenesis. This leads to reduced sperm quality and male infertility. Correcting the blood flow — either surgically or with venous tone agents like MPFF — is the basis of varicocele treatment.

If you have varicocele and are concerned about pain or fertility, Dr. Soarawee Weerasopone offers specialist consultations at Bangkok Hospital Headquarters. 진료 예약.

면책 조항: 본 내용은 방콕 병원 본사의 전문의인 Soarawee Weerasopone 박사가 작성하고 검토한 것입니다. 교육 목적으로만 제공되며 의학적 조언을 구성하지 않습니다. 모든 의학적 치료를 시작하기 전에 항상 자격을 갖춘 의료 전문가와 상담하십시오.