Peyronie’s Disease Treatment in Bangkok

Peyronie’s Disease Treatment in Bangkok

Comprehensive medical and surgical management of Peyronie’s disease (penile curvature) — from collagenase injections and traction therapy to penile plication and grafting surgery — at Bangkok Hospital Headquarters.

ត្រួតពិនិត្យផ្នែកវេជ្ជសាស្ត្រដោយវេជ្ជបណ្ឌិត Soarawee Weerasopone, MD — អ្នកជំនាញខាងប្រព័ន្ធទឹកនោមដែលមានវិញ្ញាបនបត្រ · អ្នកប្រាជ្ញស្រាវជ្រាវ និងអ្នកសង្កេតការណ៍គ្លីនិក Scott នាយកដ្ឋានប្រព័ន្ធទឹកនោម មហាវិទ្យាល័យវេជ្ជសាស្ត្រ Baylor

What Is Peyronie’s Disease?

Peyronie’s disease is a connective tissue disorder characterized by the formation of fibrous scar tissue (plaque) within the tunica albuginea of the penis. This plaque causes abnormal penile curvature, often with pain, shortening, narrowing, or erectile dysfunction. It affects an estimated 3–9% of men, with peak incidence in the 50s and 60s.

Two Clinical Phases

• Acute (Active) Phase — first 6–18 months. Characterized by pain with erection, progressive deformity, and ongoing plaque formation. Best window for medical therapy.
• Chronic (Stable) Phase — after 12–18 months. Plaque calcifies, curvature stabilizes, pain typically resolves. Surgical correction becomes the primary option.

Identifying which phase you are in determines the entire treatment plan and its timing. Read the full overview of Peyronie’s disease, including risk factors such as diabetes, low testosterone, and Dupuytren’s contracture.

អាការៈ

• Visible penile curvature (upward, downward, or lateral)
• Palpable hard nodule or plaque along the shaft
• Pain during erection (acute phase)
• Penile shortening or narrowing (“hourglass” deformity)
• Erectile dysfunction — occurring in 30–80% of Peyronie’s patients
• Psychological distress, relationship difficulties

ជម្រើសនៃការព្យាបាល

Acute Phase — Medical Therapy

• Oral therapy — Pentoxifylline, L-Carnitine, Vitamin E (limited evidence but widely used)
• Intralesional Collagenase Clostridium Histolyticum (CCH / Xiaflex) — FDA-approved injectable treatment that breaks down collagen in the plaque. Studies show 30–40% improvement in curvature. At Bangkok Hospital Headquarters, Xiaflex is available by special order only — it must be arranged and purchased in advance through the hospital pharmacy, and the cost is substantial. Please raise it early in your consultation so that timing and cost can be planned properly.
• Intralesional Verapamil — alternative injectable option for select patients
• Penile Traction Therapy — mechanical devices used 2–8 hours daily; particularly effective combined with injections
• Low-Intensity Shockwave Therapy — reduces plaque pain, less effective on curvature itself

Chronic Phase — Surgical Options

• Penile Plication — minimally invasive correction of curvature by shortening the convex (opposite) side. Best for curvature less than 60° with adequate penile length and good erectile function.
• Plaque Excision/Incision and Grafting — the plaque is excised or incised, and the defect is repaired with a graft (porcine SIS, dermal, or synthetic). Preferred for severe curvature, hourglass deformity, or short penile length.
• Penile Prosthesis with Modeling — for patients with both severe Peyronie’s disease and refractory erectile dysfunction. Provides definitive correction of curvature and ED in one procedure. ស្វែងយល់បន្ថែមអំពី IPP →

សំណួរដែលសួរញឹកញាប់

Q1: What causes Peyronie’s disease?

The exact cause is unclear, but most cases follow repetitive microtrauma during sexual activity in genetically susceptible men. Risk factors include diabetes, connective tissue disorders (Dupuytren’s contracture), prostate surgery, and aging. It is not caused by sexually transmitted infection.

Q2: Can Peyronie’s disease resolve on its own?

Spontaneous improvement occurs in less than 15% of cases, and complete resolution is rare. Most cases stabilize or progress without treatment. Early intervention during the acute phase offers the best chance of preventing severe deformity.

Q3: How effective is Xiaflex (collagenase) injection therapy?

The IMPRESS trials demonstrated approximately 30–40% improvement in curvature with a structured 4-cycle injection regimen. It is most effective for stable curvature between 30° and 90° without hourglass deformity. Results vary by patient. Please note that Xiaflex is supplied at Bangkok Hospital Headquarters by advance special order through the hospital pharmacy and is expensive, so it should be discussed and arranged well before your treatment dates.

Q4: When is surgery recommended for Peyronie’s disease?

Surgery is considered when the disease has stabilized (typically after 12 months), curvature is significant (greater than 30°), there is functional impairment of intercourse, and the patient has not responded to or declined medical therapy. The choice of procedure depends on the severity and the patient’s erectile function.

Q5: Will surgery shorten the penis?

Penile plication procedures may result in some shortening, typically less than 1–2 cm. Grafting procedures preserve length but carry a higher risk of postoperative erectile dysfunction. The choice involves balancing these trade-offs, which is discussed thoroughly during consultation.

Q6: Is Peyronie’s surgery permanent?

Yes, surgical correction provides lasting results in the vast majority of patients. Recurrence is uncommon when surgery is performed during the stable phase. Penile prosthesis with modeling provides definitive correction for patients with concurrent severe ED.

Q7: How long is recovery after Peyronie’s surgery?

Most patients return to non-strenuous activity within 1–2 weeks. Sexual activity is typically restricted for 6–8 weeks postoperatively to allow complete healing. Full results are evident at 3–6 months. International patients can return home within 7–10 days of surgery.

កក់ការពិគ្រោះយោបល់សម្ងាត់របស់អ្នក

Don’t let Peyronie’s disease define your quality of life. Effective treatment is available.
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