hCG monotherapy in male hypogonadism

Last updated: March 6, 2024

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Now a day, younger gentlemen come to see me with a hypogonadism symptom issue. Today we will discuss the new alternative way to treat this kind of disease by using hCG monotherapy with evidence-based medicine. We will pay attention in the late-onset hypogonadism which related with aging process only and here is the definition.

Hypogonadism is a state of testosterone deficiency including associated symptoms or signs, deficiency of sperm production, or both. The hypogonadism symptoms are shown below.

Symptoms of Hypogonadism

1. Sexual aspect
   • Decrease libido
   • Erectile dysfunction
   • Decrease morning erection frequency
   • Decrease sexual performance

2. Somatic aspect
   • Increase visceral fat or obesity
   • Decrease lean body mass
   • Decrease muscle strength
   • Feeling loss of energy or fatigue

3. Psychological aspect
   • Depressed mood
   • Unstable mood
   • Inability to concentrate
   • Sleep disturbance

Normally, when patients experience in those kinds of symptoms, we will have a protocol to confirm the medical diagnosis and then will consider about the testosterone replacement therapy. By the way, the testosterone replacement therapy itself has a concern of the cons on reducing fertility performance by weakening sperm strength. This why hCG or Human Chorionic Gonadotropin monotherapy was introduced and has lots of supported literatures. I will show you in detail of hCG monotherapy mechanism, pros, and cons in male hypogonadism treatment.

Characteristic of hCG

Full name	Human Chorionic Gonadotropin
Mechanism of action	Mimic LH or luteinizing hormone which stimulate intrinsic testosterone production from testis (Leydig cell)
FSH, LH and estradiol interference	No
Serum red cell concentration and PSA interference	No
Preserve fertility	Yes
How long should we prospect clinical improvement?	6 months of regular use
Injection interval time	2 times a week

From the table above, you can notice that the cons of hCG therapy seem to be much frequent injection interval when compared with exogenous testosterone replacement therapy (2 weeks up to 3 months injection interval time)

Good thing is the gentlemen who are currently using testosterone replacement therapy can safely switch to hCG monotherapy without any complication. Any questions, please talk to your trusted andrologist, or you can leave me the message.

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