What is male hypogonadism?

Male hypogonadism is a condition defined by testosterone deficiency along with associated symptoms or signs, impaired sperm production, or both. Symptoms span three areas: sexual (decreased libido, erectile dysfunction, reduced morning erections), somatic (increased body fat, reduced muscle mass and energy), and psychological (depressed mood, mood instability, poor concentration, sleep disturbance).

What is hCG and how does it treat male hypogonadism?

hCG stands for Human Chorionic Gonadotropin. It treats male hypogonadism by mimicking LH (luteinizing hormone), which stimulates the testes (specifically Leydig cells) to produce testosterone naturally from within the body, rather than replacing testosterone from an external source.

What is the advantage of hCG therapy over testosterone replacement therapy?

The key advantage of hCG monotherapy is that it preserves fertility. Standard testosterone replacement therapy can reduce sperm production and weaken sperm strength, which is a concern for men who wish to have children. hCG stimulates the body's own testosterone production without suppressing fertility.

Does hCG therapy affect FSH, LH, estradiol, red blood cells, or PSA levels?

No. hCG monotherapy does not interfere with FSH, LH, or estradiol levels, and does not affect serum red blood cell concentration or PSA levels. This makes it a favorable option compared to exogenous testosterone in men where these parameters are a concern.

How long does hCG therapy take to show results?

Clinical improvement from hCG monotherapy is generally expected after 6 months of regular use. Patients should commit to consistent treatment and follow-up with their andrologist to monitor response.

How often do I need to inject hCG for hypogonadism treatment?

hCG injections are required twice a week, which is more frequent than exogenous testosterone replacement therapy (which ranges from every 2 weeks to every 3 months depending on the formula). This higher injection frequency is the main drawback of hCG monotherapy.

hCG Monotherapy for Male Hypogonadism

Dernière mise à jour : 18 mai 2026

Soarawee Weerasopone, Urologue

Siège de l'hôpital de Bangkok, Bangkok

Hôpital Samitivej Sriracha, Chonburi

LINE Contact

Aujourd'hui, de jeunes hommes viennent me voir pour un problème de symptômes d'hypogonadisme. Aujourd'hui, nous allons discuter de la nouvelle alternative pour traiter ce type de maladie en utilisant la hCG en monothérapie avec une médecine basée sur des preuves. Nous allons nous intéresser à l'hypogonadisme tardif qui est uniquement lié au processus de vieillissement et dont voici la définition.

L'hypogonadisme est un état de carence en testostérone, avec des symptômes ou des signes associés, une déficience de la production de spermatozoïdes, ou les deux. Les symptômes de l'hypogonadisme sont présentés ci-dessous.

Symptômes de l'hypogonadisme

Sexual aspect – Decrease libido, erectile dysfunction, decrease morning erection frequency, decrease sexual performance.
Somatic aspect – Increase visceral fat or obesity, decrease lean body mass, decrease muscle strength, feeling loss of energy or fatigue.
Psychological aspect – Depressed mood, unstable mood, inability to concentrate, sleep disturbance.

La perte de libido est un signe d'hypogonadisme.

Normally, when patients experience in those kinds of symptoms, we will have a protocol to confirm the medical diagnosis and then will consider about the testosterone replacement therapy. By the way, the testosterone replacement therapy itself has a concern of the cons on reducing fertility performance by weakening sperm strength. This why hCG or Human Chorionic Gonadotropin monotherapy was introduced and has lots of supported literatures.

Caractéristiques de l'hCG

Nom complet	Gonadotrophine chorionique humaine
Mécanisme d'action	Mimic LH or luteinizing hormone which stimulate intrinsic testosterone production from testis (Leydig cell)
Interférence de la FSH, de la LH et de l'estradiol	Non
Concentration sérique de globules rouges et interférence du PSA	Non
Préserver la fertilité	Oui
Combien de temps faut-il attendre une amélioration clinique ?	6 mois d'utilisation régulière
Durée de l'intervalle d'injection	2 fois par semaine

From the table above, you can notice that the cons of hCG therapy seem to be much frequent injection interval when compared with exogenous testosterone replacement therapy.

La bonne nouvelle est que les hommes qui utilisent actuellement une thérapie de remplacement de la testostérone peuvent passer en toute sécurité à la monothérapie par l'hCG sans aucune complication. Si vous avez des questions, n'hésitez pas à en parler à votre andrologue de confiance ou à me laisser un message.

Vous pouvez visiter ma page d'accueil officielle ici.

Foire aux questions (FAQ)

Q1: What is hCG and how does it work in male hypogonadism?

hCG (Human Chorionic Gonadotropin) is a hormone that mimics LH (luteinizing hormone), stimulating the Leydig cells in the testes to produce testosterone naturally. Unlike conventional testosterone replacement therapy, hCG works by stimulating the body’s own testosterone production rather than replacing it from an external source.

Q2: Who is the best candidate for hCG monotherapy?

hCG monotherapy is particularly suitable for younger men with hypogonadism who wish to preserve their fertility. Since conventional testosterone replacement therapy suppresses sperm production, hCG offers an alternative that treats testosterone deficiency while maintaining fertility potential. Your urologist will assess your hormone profile and fertility goals before recommending this option.

Q3: What is the difference between hCG monotherapy and testosterone replacement therapy?

Testosterone replacement therapy (TRT) delivers exogenous testosterone directly into the body, which can suppress natural testosterone and sperm production. hCG monotherapy stimulates the testes to produce testosterone internally, preserving fertility. hCG requires injection twice a week, whereas TRT injections range from every 2 weeks to every 12 weeks depending on the formula.

Q4: How long does it take to see results from hCG monotherapy?

Clinical improvement from hCG monotherapy is typically expected after approximately 6 months of regular treatment. Symptoms such as low energy, reduced libido, and mood changes should gradually improve as testosterone levels normalize. Regular follow-up with blood tests is essential to monitor progress and adjust the treatment plan.

Q5: Can I switch from testosterone replacement therapy to hCG monotherapy?

Yes. Men who are currently on testosterone replacement therapy can safely transition to hCG monotherapy without major complications. However, this switch should always be done under the supervision of a qualified urologist or andrologist, with appropriate monitoring of hormone levels throughout the transition period.

If you are experiencing symptoms of hypogonadism and would like a comprehensive evaluation, Dr. Soarawee Weerasopone offers specialist consultations in men’s health and testosterone therapy at Bangkok Hospital Headquarters. Prendre rendez-vous.

Avis de non-responsabilité : Ce contenu est rédigé et revu par le Dr Soarawee Weerasopone, urologue certifié au siège de Bangkok Hospital. Il est destiné uniquement à des fins éducatives et ne constitue pas un avis médical. Consultez toujours un professionnel de la santé qualifié avant de commencer tout traitement médical.

Rédigé et révisé par des médecins : Dr. Soarawee Weerasopone (Dr. Pom) – Urologue certifié, Hôpital de Bangkok (siège). Fellowship international : Baylor College of Medicine (États-Unis) · Juntendo University (Japon) · Chang Gung Memorial Hospital (Taïwan).

Dr. Soarawee Weerasopone

Le Dr Soarawee Weerasopone (Dr Pom) est un urologue certifié au Bangkok Hospital Headquarters, spécialisé dans la santé masculine, la chirurgie robotique (système Da Vinci) et le traitement des calculs rénaux. Il a effectué des bourses internationales au Baylor College of Medicine (États-Unis), à l'hôpital universitaire Juntendo (Japon) et à l'hôpital commémoratif Chang Gung (Taïwan). Tout le contenu médical de ce site est rédigé et révisé par le Dr Soarawee, sur la base de son expérience clinique et de sa formation internationale.