What is the difference between Gardasil 9 and Gardasil 4?

Gardasil 4 protects against HPV subtypes 6, 11, 16, and 18. Gardasil 9 protects against those same 4 subtypes plus 5 additional ones: HPV 31, 33, 45, 52, and 58, offering broader coverage.

How effective is Gardasil 9 against cervical cancer compared to Gardasil 4?

Gardasil 4 provides approximately 70% protection against cervical cancer, while Gardasil 9 provides approximately 90% protection — a significant improvement in coverage.

Does Gardasil protect men against penile cancer?

Current evidence shows that Gardasil vaccination does provide HPV protection in men with some benefit against penile cancer, though the cost-effectiveness in males is considered lower than in females based on available literature.

How effective is Gardasil 4 against genital warts?

Gardasil 4 has been reported to provide approximately 77% protection against genital warts. Gardasil 9 is expected to offer even greater protection, though updated efficacy data specific to genital warts for Gardasil 9 is still pending.

Do I get any protection from the first dose of Gardasil before completing all 3 injections?

Yes. A study from Spain in 2017 showed that a single dose of Gardasil 4 provided approximately 61% protection. However, it is unclear how long this partial protection lasts, so completing all 3 doses at months 0, 2, and 6 is still recommended.

Can I still benefit from Gardasil vaccination if I have already had an HPV infection?

Yes. A large study of 18,174 women published in 2009 confirmed that Gardasil still provides meaningful protection against other HPV subtypes even in patients who have had a prior HPV infection.

Is Gardasil 9 worth the extra cost compared to Gardasil 4?

Gardasil 9 is more expensive than Gardasil 4 but offers broader protection against 9 HPV subtypes versus 4, and higher efficacy against cervical cancer (90% vs 70%). Whether it is worth the additional cost depends on individual circumstances — discuss with your urologist or doctor.

Gardasil 9 vs Gardasil 4: Which HPV Vaccine?

最終更新日： 4月 30, 2026

ソアラウィー・ウィーラソポーン、泌尿器科医

バンコク病院本部、バンコク

サミティヴェートシラチャー病院、チョンブリー

ラインコンタクト

私のオフィスにいる多くの患者が、これらのHPVワクチン接種、Gardasil9とGardasil4の違いについて尋ねたとき、この記事では、これらすべての質問に詳細に答えます。

Several gentlemen have questions on Gardasil 9 vaccination.

Gardasil 9 FAQ

Which HPV subtypes are covered?

Gardasil 4: covers HPV 6, 11, 16, and 18.
Gardasil 9: covers HPV 6, 11, 16, 18, 31, 33, 45, 53, and 58 — 5 additional high-risk strains.

Protection rate against cervical cancer?

Gardasil 4: approximately 70% protection.
Gardasil 9: approximately 90% protection.

Gardasil 9 can protect men against penile cancer and genital warts.

Protection against genital warts?

Gardasil 4: approximately 77% protection.
Gardasil 9: expected to provide higher protection, though updated efficacy data for genital warts is still pending.

Can partial vaccination (1 jab) provide protection?

Yes. A 2017 Spanish study showed 61% protection after just 1 Gardasil-4 injection, though the duration of this partial protection is unclear. A complete 3-dose course (at 0, 2, and 6 months) is still recommended for maximum protection.

Can previously HPV-infected patients still benefit from vaccination?

Yes. A 2009 study of 18,174 women showed Gardasil still provides significant protection even in those with prior HPV infection, as vaccination protects against strains not previously encountered.

Patients still get benefit from Gardasil 9 even with previous HPV infection history.

Gardasil 9 is a bit more costly than Gardasil 4, but offers significantly broader protection. Any question, talk to your trusted urologist, or it would be my honor if you text me. Take care!

私の公式ウェブサイトにアクセスできますここ.

お客様からよくいただくご質問

Q1: What is the main difference between Gardasil 9 and Gardasil 4?

Gardasil 9 covers 9 HPV strains (6, 11, 16, 18, 31, 33, 45, 53, 58) while Gardasil 4 covers only 4 strains (6, 11, 16, 18). The 5 additional strains in Gardasil 9 are high-risk cancer-causing types. This broader coverage translates into approximately 90% protection against cervical cancer with Gardasil 9 versus approximately 70% with Gardasil 4, making Gardasil 9 the superior choice where available.

Q2: Should men get the Gardasil HPV vaccination?

Yes. While HPV vaccination is most studied and cost-effective in females, men can still benefit significantly. HPV vaccination in men reduces the risk of penile cancer, anal cancer, oropharyngeal cancer, and genital warts. HPV strains 6 and 11 (covered by both Gardasil 4 and 9) cause approximately 90% of genital warts cases. Vaccination before first sexual exposure offers the highest protection.

Q3: How many doses of Gardasil are needed?

A complete HPV vaccination course consists of 3 injections given at 0, 2, and 6 months. For individuals aged 9-14 who start the series early, a 2-dose schedule may be sufficient. Even a single dose provides some protection (approximately 61% based on Gardasil-4 data), but completing the full course is strongly recommended for maximum and most durable protection.

Q4: Is it worth getting Gardasil 9 if I have already been infected with HPV?

Yes. Even if you have had a prior HPV infection, vaccination still provides significant benefit by protecting against HPV strains you have not yet been exposed to. A landmark 2009 study of over 18,000 women confirmed that Gardasil provides meaningful protection even in individuals with prior HPV infection. Your urologist can advise whether vaccination is appropriate based on your specific HPV history.

Q5: Is Gardasil 9 worth the higher cost compared to Gardasil 4?

In most clinical settings, yes. The additional 20% improvement in cervical cancer protection (90% vs 70%) and coverage of 5 extra high-risk HPV strains make Gardasil 9 the preferred choice from a medical standpoint. While Gardasil 9 is more expensive, the broader protection against cancer-causing strains represents significant long-term health value. Your doctor can help you make an informed decision based on your individual risk profile and budget.

If you would like to discuss HPV vaccination or sexual health screening, Dr. Soarawee Weerasopone offers specialist consultations at Bangkok Hospital Headquarters. 相談を予約する.

**免責事項:** このコンテンツは、バンコク病院本部の認定泌尿器科医であるSoarawee Weerasopone博士によって作成およびレビューされました。教育目的のみのものであり、医学的アドバイスを構成するものではありません。いかなる医療処置を開始する前にも、必ず資格のある医療専門家にご相談ください。.

医学的に記述・監修： ソアラウィー・ウィーラソポーン医師（ポム医師） — バンコク病院本社泌尿器科専門医。国際フェロー：ベイラー医科大学（米国）、順天堂大学（日本）、長庚紀念医院（台湾）。.

ソアラウィー・ウィーラソポーネ博士

ソアラウィー・ウィーラソポーン医師（ポム医師）は、バンコク病院本院の泌尿器科専門医で、男性医学、ロボット手術（ダヴィンチシステム）、腎結石治療を専門としています。ベイラー医科大学（米国）、順天堂大学医学部附属順天堂医院（日本）、長庚記念医院（台湾）での国際フェローシップを修了しています。このサイトのすべての医療コンテンツは、ソアラウィー医師の臨床経験と国際的なトレーニングに基づいて、同医師によって作成・監修されています。.

。。。。