শেষ আপডেট: এপ্রিল ২৯, ২০২৬

Peyronie’s disease (PD) is a non-malignant disorder of the penis characterized by abnormal penile curvature during erection, first described by French physician François Gigot de la Peyronie in 1749. Due to embarrassment, it is significantly underreported — it is estimated to affect more than 10% of men in the USA. PD causes major psychological distress and is frequently associated with erectile dysfunction.

The abnormal curvature is caused by scar tissue (plaque) forming on the wall of the penile erectile tissue known as the Tunica albuginea.

Peyronie disease plaque scar tunica albuginea
Peyronie’s disease involves the same scarring process that occurs in other tissues — but located on the penile erectile wall.

পেরোনি রোগ risk factors

  1. পেনাইল ইনজুরির ইতিহাস — sexual-related penile trauma, genital or perineal trauma, or iatrogenic injury (catheterization, cystoscopy, endoscopic surgery)
  2. সংযোগকারী টিস্যু ব্যাধি — PD is strongly associated with Dupuytren’s contracture and plantar fasciitis, conditions sharing the same superficial scarring pathology
  3. পেরোনি রোগের পারিবারিক ইতিহাস — genetic susceptibility increases the likelihood of developing PD following penile trauma
  4. হাইপোগোনাডিজম — testosterone plays an essential role in normal wound healing in the genital area. Significant PD is reported more frequently in patients with testosterone levels below 300 ng/dL
  5. Diabetes mellitus — impairs the healing process; PD is reported at 5 times the rate in diabetic men compared to the general population
  6. ধূমপান এবং অ্যালকোহল — some evidence suggests association with PD, though the dose-response relationship remains unclear
  7. Age over 60 — the most commonly affected patient subgroup
Peyronie disease erection pain acute phase
Painful erection is the hallmark symptom of the acute phase of Peyronie’s disease.

Phases of Peyronie’s disease

  1. Acute phase (first 6–18 months) — penile deformity is still progressing; painful erection is the major complaint. Specific treatment is NOT recommended at this stage — only pain control and supplements are appropriate
  2. Chronic phase — penile curvature has stabilized; pain is absent or minimal. Specific treatment for the disease is recommended in this phase

Diagnosis involves careful physical examination in both flaccid and erect states, documenting degree of curvature, plaque size and location, and pain on palpation. Optional imaging includes conventional ultrasound, penile Doppler ultrasound, or MRI of the penis.

Peyronie disease oral medication
Oral medications per AUA guidelines show benefit in Peyronie’s disease management.

চিকিৎসার বিকল্প

  1. Nonsurgical management:
    • Oral medications — per American Urological Association (AUA) guidelines: NSAIDs, oral Vitamin E, and Omega-3 are recommended
    • Intralesional injections — anti-plaque agents injected directly into the plaque have demonstrated benefit
  2. Surgical management:
    • Recommended when nonsurgical treatment has failed or outcomes are unsatisfactory
    • Appropriate timing: at least 3 months of stable, pain-free deformity
    • Possible surgical complications include: erectile dysfunction, penile shortening, penile instability, persistent pain, and recurrence of curvature
Peyronie disease surgery
Surgical correction is recommended after at least 3 months of stable, pain-free deformity.

Peyronie’s disease carries a good prognosis when treated appropriately. Early medical advice is essential. Any questions, contact me through the social links on this website.

Frequently Asked Questions About Peyronie’s Disease

What causes Peyronie’s disease and who is at risk?

Peyronie’s disease is caused by scar tissue (plaque) forming on the Tunica albuginea, the fibrous wall surrounding the penile erectile tissue. The most significant risk factors include a history of penile injury (sexual trauma, iatrogenic injury from catheterization or cystoscopy), connective tissue disorders (Dupuytren’s contracture, plantar fasciitis), family history of PD, hypogonadism (testosterone below 300 ng/dL), diabetes mellitus (5× higher incidence), smoking, alcohol, and age over 60.

What is the difference between the acute and chronic phase of Peyronie’s disease?

The acute phase lasts 6–18 months from onset. During this phase, the penile curvature is still changing and painful erection is the dominant symptom. Specific anti-curvature treatment is not recommended in the acute phase — management focuses on pain control and supplements. The chronic phase begins once the curvature has stabilized and pain has resolved or become minimal. This is when definitive treatment — nonsurgical (intralesional injections) or surgical correction — should be considered.

What are the treatment options for Peyronie’s disease?

Nonsurgical options include oral medications (NSAIDs, Vitamin E, Omega-3 per AUA guidelines) and intralesional anti-plaque injections directly into the scar tissue. Surgical correction is considered after at least 3 months of stable, pain-free deformity when nonsurgical treatment has been insufficient. Surgical risks include erectile dysfunction, penile shortening, instability, and curvature recurrence. The best timing and approach are individualized based on the patient’s specific deformity, erectile function, and treatment history.

If you are concerned about penile curvature or other andrological conditions, Dr. Soarawee Weerasopone offers specialist consultations at Bangkok Hospital Headquarters. পরামর্শের জন্য একটি বুকিং করুন.

**দাবি পরিত্যাগ:** এই বিষয়বস্তুটি ডঃ সোয়ারউই উইরাসোপোন, ব্যাংকক হাসপাতাল হেডকোয়ার্টার্সের বোর্ড-সার্টিফাইড ইউরোলজিস্ট রচনা ও পর্যালোচনা করেছেন। এটি শুধুমাত্র শিক্ষাগত উদ্দেশ্যে তৈরি করা হয়েছে এবং এটি চিকিৎসা পরামর্শ গঠন করে না। কোনও চিকিৎসা শুরু করার আগে সর্বদা একজন যোগ্যতাসম্পন্ন স্বাস্থ্যসেবা পেশাদারের সাথে পরামর্শ করুন।.

মেডিকেল লেখা এবং পর্যালোচিত: ডঃ সোয়ারউই উইরাসোপোন (ডঃ পম) — বোর্ড-সার্টিফাইড ইউরোলজিস্ট, ব্যাংকক হাসপাতাল হেডকোয়ার্টার্স। আন্তর্জাতিক ফেলো: বেইলর কলেজ অফ মেডিসিন (ইউএসএ) · জুনটেন্ডো ইউনিভার্সিটি (জাপান) · চ্যাং গাং মেমোরিয়াল হাসপাতাল (তাইওয়ান)।.

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Dr. Soarawee Weerasopone — Urologist Bangkok থেকে আরও আবিষ্কার করুন

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