Testosterone replacement therapy: Head-to-head comparison

Last updated: May 18, 2026

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After patients have decided to start Testosterone replacement therapy via intramuscular injection route, then we go through this question “Which testosterone formula is suitable for individuals?” Today we will compare between 2 intramuscular injection preparation, Testosterone enanthate & Testosterone undecanoate.

There are several literatures confirmed that the injection’s formula can improve both sexual behaviors and general well-being parameters significantly after 30 weeks of a regular treatment.

Sexual behaviors parameters which show the improvement

1. Sexual visualization
2. Sexual desirable
3. Sexual satisfaction
4. Numbers of ejaculations per week
5. Number of erections per week
6. Number of morning erections per week

General well-being parameters which show the improvement

1. More focusing
2. Agitating
3. Self-confidence
4. Less dizziness
5. More active
6. Better moody

I will make comparisons between those 2 intramuscular formulas in the following table below.

Testosterone replacement therapy formulas

	Testosterone enanthate	Testosterone undecanoate
Generic name	Testosterone enanthate	Testosterone undecanoate
Strength	250 mg	1000 mg
Interval injection period	3 weeks	12 weeks
Site of injection	Buttock or thigh	Buttock
Self-injection option	Yes	No

Now you can see pros and cons between Testosterone enanthate & Testosterone undecanoate, the options are depended on you. Any questions, you can talk or discuss with your trusted Andrologist on the tailer-made testosterone replacement therapy or it would be my honor if you text me. Bye!

You can visit my official homepage here.

Frequently Asked Questions

Q1: What is the difference between Testosterone enanthate and Testosterone undecanoate?

Testosterone enanthate (Testoviron) is a 250mg injection given every 2-3 weeks and can be self-injected into the thigh. Testosterone undecanoate (Nebido) is a 1000mg injection given every 12 weeks but must be administered by a healthcare professional at the buttock. The choice depends on your lifestyle, preference, and clinical assessment by your urologist.

Q2: Can I self-inject Testosterone undecanoate (Nebido) at home?

No. Testosterone undecanoate must be administered at the buttock by a trained healthcare professional due to the large volume of the injection. Only Testosterone enanthate (Testoviron) is suitable for self-injection at the thigh, and only after proper training and supervision by a medical professional.

Q3: How long does it take to see results from testosterone injection therapy?

Clinical studies show that both sexual behavior and general well-being parameters including energy, mood, libido, and muscle mass show significant improvement after approximately 30 weeks of regular testosterone injection therapy. Individual results may vary depending on baseline testosterone levels and overall health.

Q4: Which testosterone injection formula is better for someone with a busy schedule?

Testosterone undecanoate (Nebido) may be more convenient for men with busy schedules, as it only requires an injection every 12 weeks compared to every 2-3 weeks for Testosterone enanthate. However, each injection requires a clinic visit. Your urologist will recommend the most appropriate formula based on your individual testosterone levels and lifestyle.

Q5: Is testosterone injection therapy safe long-term?

When properly monitored by a qualified urologist, testosterone injection therapy is considered safe for most men with confirmed testosterone deficiency. Regular monitoring of blood parameters including hematocrit, PSA, and testosterone levels is essential to ensure safety and adjust dosing as needed. Always consult your doctor before starting or modifying any testosterone treatment.

If you are considering testosterone replacement therapy and would like a comprehensive evaluation, Dr. Soarawee Weerasopone offers specialist consultations in men’s health and testosterone therapy at Bangkok Hospital Headquarters. Book a Consultation.

Disclaimer: This content is written and reviewed by Dr. Soarawee Weerasopone, a board-certified urologist at Bangkok Hospital Headquarters. It is intended for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any medical treatment.