Dernière mise à jour : 18 mai 2026

La syphilis est un type de maladie sexuellement transmissible que l'on rencontre fréquemment dans mon cabinet. Le tableau clinique varie d'un ulcère génital indolore à une éruption cutanée au niveau de la paume et de la plante des pieds, en fonction du stade de l'infection. Le test sanguin est le seul moyen de confirmer le diagnostic de la maladie, mais le problème est le suivant, chaque test sanguin présente des avantages et des inconvénients. Most of patients more likely confusing on it, especially, when their test confirmed positive. And the other thing while they didn’t have a full explanation from physicians it will mislead them to seek out another second opinions or advices. In this topic, we will figure out about the difference type of the tests and how to use them wisely.

Syphilis : La confusion sur les différents types de tests sanguins
Le seul moyen de diagnostiquer la syphilis est le test sanguin.

Tests contreponémiques - il s'agit d'un "test de dépistage" pour les infections suspectes de syphilis. Le plus souvent, nous utilisons ce test dans le cadre d'une investigation primaire. Le pour, c'est la capacité de détection d'une infection syphilitique active qui sert à retracer la possibilité d'un traitement, qu'il soit efficace ou non.

Tests de dépistage de la syphilis non contreponémique courants au Cambodge

  1. VDRL (Laboratoire de recherche sur les maladies vénériennes)
  2. RPR (réactivité plasmatique rapide)

Treponemal tests – it would be named as a “Confirmation tests”. If anyone got positive test from VDRL or RPR, it must do the reconfirming diagnosis with treponemal tests. The pro of this test is, it was very accuracy but unfortunately, we don’t know that the syphilis is currently in the active stage or not, that is the weak point of it. Additionally, the treponemal test will always positive in whole your life even a completely cured were done. Therefore, we cannot rely on the tracing’s treatment outcome via the treponemal tests only. This is why the patient must be carefully and pay attention more on the explanation about this information.

Tests courants de dépistage de la syphilis tréponémique au Cambodge

  1. TP-PA (agglutination de particules de Treponemal Pallidum)
  2. FTA-ABS (anticorps tréponémique fluorescent absorbé)
Une bonne compréhension des tests permet d'obtenir les meilleurs résultats et de renforcer la relation médecin-patient.

Syphilis is a common disease that very easy to get treated, but the important thing is, how to make your treatment correctly and get educated your patient properly. When the patients educated and fully understanding about their problems and they can actually knowing how to trace the disease that currently they are in, then they will never and ever experience in the panic condition any more. So the point is, you need probably binding a good communication and relations a little stronger than before in order to get a high success treatment and cure on this kind of disease – syphilis. Have a good day.

Si vous avez des questions, n'hésitez pas à vous adresser à moi.

If you have concerns about syphilis blood test results or need diagnosis and treatment for a sexually transmitted infection, Dr. Soarawee Weerasopone offers confidential specialist consultations at Bangkok Hospital Headquarters. Prendre rendez-vous.

Frequently Asked Questions about Syphilis Blood Tests

What is the difference between nontreponemal and treponemal syphilis tests?

Nontreponemal tests (VDRL, RPR) are used as screening tests to detect active syphilis infection and to monitor treatment response. Treponemal tests (TP-PA, FTA-ABS) are confirmation tests that are highly specific for syphilis but remain positive for life even after successful treatment, so they cannot be used alone to assess treatment outcome.

If my VDRL or RPR is positive, does it mean I have syphilis?

A positive VDRL or RPR is a strong indicator but not a definitive diagnosis. These screening tests can occasionally produce false positives due to other conditions such as autoimmune diseases or viral infections. A confirmatory treponemal test (TP-PA or FTA-ABS) is always required to make a definitive diagnosis of syphilis.

Why does my treponemal test stay positive even after treatment?

Treponemal tests detect specific antibodies against the syphilis bacterium that persist in the bloodstream for life once produced, even after the infection has been completely cured. This is a normal finding and does not mean the infection is still active. Treatment success is monitored using nontreponemal tests (VDRL or RPR), which should show a declining titer after effective treatment.

How do doctors know if syphilis treatment is working?

Treatment response is tracked by monitoring the VDRL or RPR titer over time. After successful treatment, the nontreponemal titer should decrease fourfold or more within 6–12 months. A stable or rising titer may indicate treatment failure or reinfection, requiring further evaluation by a specialist.

Is syphilis curable?

Yes, syphilis is highly curable, especially when diagnosed and treated early. The standard treatment is penicillin G injection, with the dose and duration depending on the stage of infection. Early diagnosis, correct treatment, and regular follow-up blood tests are essential to ensure complete cure and prevent complications or transmission to partners.

Avis de non-responsabilité : Ce contenu est rédigé et revu par le Dr Soarawee Weerasopone, urologue certifié au siège de Bangkok Hospital. Il est destiné uniquement à des fins éducatives et ne constitue pas un avis médical. Consultez toujours un professionnel de la santé qualifié avant de commencer tout traitement médical.

Rédigé et révisé par des médecins : Dr. Soarawee Weerasopone (Dr. Pom) – Urologue certifié, Hôpital de Bangkok (siège). Fellowship international : Baylor College of Medicine (États-Unis) · Juntendo University (Japon) · Chang Gung Memorial Hospital (Taïwan).

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