{"id":9635,"date":"2026-05-05T20:00:00","date_gmt":"2026-05-05T13:00:00","guid":{"rendered":"https:\/\/drsoaraweeurology.com\/?p=9635"},"modified":"2026-05-01T01:51:06","modified_gmt":"2026-04-30T18:51:06","slug":"testosterone-therapy-depression-mens-health","status":"publish","type":"post","link":"https:\/\/drsoaraweeurology.com\/th\/2026\/05\/05\/testosterone-therapy-depression-mens-health\/","title":{"rendered":"\u0e01\u0e32\u0e23\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e14\u0e49\u0e27\u0e22\u0e2e\u0e2d\u0e23\u0e4c\u0e42\u0e21\u0e19\u0e40\u0e1e\u0e28\u0e0a\u0e32\u0e22: \u0e1e\u0e31\u0e19\u0e18\u0e21\u0e34\u0e15\u0e23\u0e43\u0e2b\u0e21\u0e48\u0e17\u0e35\u0e48\u0e2d\u0e32\u0e08\u0e0a\u0e48\u0e27\u0e22\u0e15\u0e48\u0e2d\u0e2a\u0e39\u0e49\u0e01\u0e31\u0e1a\u0e20\u0e32\u0e27\u0e30\u0e0b\u0e36\u0e21\u0e40\u0e28\u0e23\u0e49\u0e32?"},"content":{"rendered":"\n<p><strong>Last updated:<\/strong> May 5, 2026<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img 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1.86v.4l-1.65.16c-1.35.13-1.86.46-1.86 1.13v.04c0 .67.41 1.06 1.45 1.06.85 0 1.55-.32 1.93-.84.04-.06.13-.07.18-.02.05.03.07.1.07.16v.43c0 .26.13.42.34.42h1.05c.21 0 .34-.16.34-.42v-3.6c0-1.94-1.13-2.83-3.46-2.83-1.94 0-3.07.86-3.4 2.04l1.55.45c.18-.69.6-1.04 1.83-1.04zM2.135 16.314c-.587 0-1.066-.156-1.434-.469-.367-.312-.618-.704-.752-1.176-.034-.124-.061-.232-.082-.327a3.794 3.794 0 0 1-.044-.366 8.83 8.83 0 0 1-.022-.547C0 13.221 0 12.985 0 12.704c0-.281 0-.515.001-.704a8.81 8.81 0 0 1 .022-.547 3.802 3.802 0 0 1 .044-.366c.02-.094.048-.203.082-.328.134-.471.385-.864.752-1.176.368-.313.847-.469 1.434-.469.477 0 .892.087 1.246.262.353.175.622.443.806.804.044.083.083.157.117.222.034.066.069.144.105.235.022.054.011.099-.034.135l-.66.292c-.045.027-.082.013-.112-.045a4.043 4.043 0 0 0-.155-.27 1.247 1.247 0 0 0-.49-.495c-.225-.131-.522-.196-.892-.196-.402 0-.726.064-.972.193-.247.13-.422.302-.527.518-.027.045-.054.099-.082.16a1.39 1.39 0 0 0-.067.197 2.46 2.46 0 0 0-.05.282 5.51 5.51 0 0 0-.033.43c-.008.17-.013.376-.013.617 0 .242.005.448.013.618.008.17.02.314.034.43.013.117.03.21.05.282.02.072.042.137.066.197.105.216.28.39.527.518.246.13.57.193.972.193.4 0 .714-.07.94-.21.227-.14.394-.346.503-.617a2.43 2.43 0 0 0 .104-.395c.018-.123.027-.282.027-.477V13.2H2.34c-.04 0-.06-.02-.06-.062v-.5c0-.04.02-.062.06-.062h1.812c.04 0 .062.02.062.06v.5c0 .156-.005.296-.014.422a4.71 4.71 0 0 1-.04.342 1.732 1.732 0 0 1-.064.262c-.13.523-.402.913-.815 1.17-.413.255-.95.382-1.61.382z\"\/>\n    <\/svg>\n  <\/a>\n  \n  <a href=\"https:\/\/orcid.org\/0009-0004-8387-3559\" \n     target=\"_blank\" \n     rel=\"noopener\"\n     title=\"ORCID iD\"\n     aria-label=\"View ORCID Profile\"\n     style=\"text-decoration: none; color: #A6CE39; transition: transform 0.2s; display: inline-block;\"\n     onmouseover=\"this.style.transform='scale(1.15)'\"\n     onmouseout=\"this.style.transform='scale(1)'\">\n    <svg width=\"28\" height=\"28\" viewBox=\"0 0 24 24\" fill=\"currentColor\">\n      <path d=\"M12 0C5.372 0 0 5.372 0 12s5.372 12 12 12 12-5.372 12-12S18.628 0 12 0zM7.369 4.378c.525 0 .947.431.947.947 0 .525-.422.947-.947.947-.525 0-.946-.422-.946-.947 0-.525.421-.947.946-.947zm-.722 3.038h1.444v10.041H6.647V7.416zm3.562 0h3.9c3.712 0 5.344 2.653 5.344 5.025 0 2.578-2.016 5.025-5.325 5.025h-3.919V7.416zm1.444 1.303v7.444h2.297c3.272 0 4.022-2.484 4.022-3.722 0-2.016-1.284-3.722-4.097-3.722h-2.222z\"\/>\n    <\/svg>\n  <\/a>\n  \n  <a href=\"https:\/\/scholar.google.com\/citations?user=lTgsRMUAAAAJ&#038;hl=en\" \n     target=\"_blank\" \n     rel=\"noopener\"\n     title=\"Google Scholar\"\n     aria-label=\"View Google Scholar Profile\"\n     style=\"text-decoration: none; color: #4285F4; transition: transform 0.2s; display: inline-block;\"\n     onmouseover=\"this.style.transform='scale(1.15)'\"\n     onmouseout=\"this.style.transform='scale(1)'\">\n    <svg width=\"28\" height=\"28\" viewBox=\"0 0 24 24\" fill=\"currentColor\">\n      <path d=\"M5.242 13.769L0.5 9.5 12 1l11.5 8.5-4.742 4.269C17.548 11.249 14.978 9.5 12 9.5c-2.977 0-5.548 1.748-6.758 4.269zM12 10a7 7 0 1 0 0 14 7 7 0 0 0 0-14z\"\/>\n    <\/svg>\n  <\/a>\n  \n<\/div>\n\n\n\n<p>For many men, depression is more than just feeling &#8220;blue&#8221; \u2014 it\u2019s a heavy mix of persistent low mood, negative thoughts, and physical fatigue. While standard antidepressants are the go-to treatment, they only show modest effects for some, and about <strong>30% of patients don\u2019t find lasting relief<\/strong> even after trying multiple medications.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"600\" data-attachment-id=\"10168\" data-permalink=\"https:\/\/drsoaraweeurology.com\/th\/2026\/05\/05\/testosterone-therapy-depression-mens-health\/testosterone-depression-6-key-findings\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?fit=800%2C600&amp;ssl=1\" data-orig-size=\"800,600\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Testosterone Therapy and Depression &amp;#8211; 6 Key Findings JAMA 2019\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?fit=800%2C600&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=800%2C600&#038;ssl=1\" alt=\"Testosterone Therapy and Depression in Men \u2014 6 key findings from 2019 JAMA Psychiatry meta-analysis: tested on 1,900+ men, cuts depression by 50% or more, works like antidepressants, effective even in normal-T men, results in 3 to 6 weeks. Summary by Dr. Soarawee Weerasopone, urologist at Bangkok Hospital\" class=\"wp-image-10168\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?w=800&amp;ssl=1 800w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=16%2C12&amp;ssl=1 16w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=600%2C450&amp;ssl=1 600w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=400%2C300&amp;ssl=1 400w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Depression-%E2%80%94-6-Key-Findings.jpg?resize=200%2C150&amp;ssl=1 200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">Testosterone Therapy and Depression \u2014 6 key findings from the 2019 JAMA Psychiatry meta-analysis.<\/figcaption><\/figure>\n\n\n\n<p>During my fellowship at Baylor College of Medicine with Professor Mohit Khera, he often reminded me that low testosterone can quietly drive depression in men. That insight is exactly why I wanted to write this post.<\/p>\n\n\n\n<p>As a urologist specializing in Men\u2019s Health, I often remind my patients that testosterone is far more than a &#8220;sex hormone&#8221; \u2014 it is a systemic hormone that influences mood, energy, and cognition. In my earlier post, I explained why <a href=\"https:\/\/drsoaraweeurology.com\/2026\/04\/21\/testosterone-barometer-mens-health\/\">testosterone is the ultimate barometer of a man\u2019s overall health<\/a>. A major 2019 study published in <em>JAMA Psychiatry<\/em> suggests that this same &#8220;Testosterone Barometer&#8221; may also be a key factor in improving men\u2019s mental health.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the Research Found<\/h2>\n\n\n\n<p>Researchers analyzed 27 different clinical trials involving nearly 1,900 men to see if testosterone treatment could help lift depressive symptoms. The results were published in <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30427999\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>JAMA Psychiatry<\/em><\/a> and they are striking.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1. It Actually Works<\/h3>\n\n\n\n<p>The study found that testosterone treatment was associated with a <strong>significant reduction in depressive symptoms<\/strong>. In fact, the treatment was <strong>twice as likely<\/strong> to result in a major (50% or more) reduction in depression scores compared to a placebo. These results are comparable to the effectiveness of many current antidepressants.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2. Higher Doses May Be Key<\/h3>\n\n\n\n<p>The benefits were most noticeable when men received higher-dosage regimens. Specifically, the treatment remained clinically significant whenever dosages <strong>greater than 0.5 g (500 mg) per week<\/strong> were administered.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3. It\u2019s Not Just for &#8220;Low-T&#8221;<\/h3>\n\n\n\n<p>Surprisingly, the antidepressant effects <strong>did not depend on how much testosterone a man had to begin with<\/strong>. Both hypogonadal (clinically low testosterone) and eugonadal (normal testosterone) men showed improvement, as did both younger and older men.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1280\" height=\"1920\" data-attachment-id=\"9338\" data-permalink=\"https:\/\/drsoaraweeurology.com\/th\/2026\/04\/21\/testosterone-barometer-mens-health\/pexels-mikhail-nilov-7534781\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?fit=1280%2C1920&amp;ssl=1\" data-orig-size=\"1280,1920\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"pexels-mikhail-nilov-7534781\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?fit=683%2C1024&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=683%2C1024&amp;ssl=1\" alt=\"Man experiencing depression and low mood \u2014 testosterone therapy may help alleviate symptoms in men\" class=\"wp-image-9338\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?w=1280&amp;ssl=1 1280w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=200%2C300&amp;ssl=1 200w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=683%2C1024&amp;ssl=1 683w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=768%2C1152&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=1024%2C1536&amp;ssl=1 1024w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=1365%2C2048&amp;ssl=1 1365w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=8%2C12&amp;ssl=1 8w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-mikhail-nilov-7534781.webp?resize=1200%2C1800&amp;ssl=1 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Is It Safe and Easy to Use?<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>High Acceptability:<\/strong> Men in the studies were no more likely to drop out of testosterone treatment than those taking a placebo, suggesting the treatment is generally well-tolerated and serious side effects are rare.<\/li>\n\n\n\n<li><strong>Flexible Options:<\/strong> The positive effects were seen across different methods of application, including <strong>gels (transdermal), injections (intramuscular), and oral medications<\/strong>.<\/li>\n\n\n\n<li><strong>Quick Onset:<\/strong> While every person is different, some men began to see improvements in as little as <strong>3 to 6 weeks<\/strong>.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"8192\" height=\"6144\" data-attachment-id=\"9340\" data-permalink=\"https:\/\/drsoaraweeurology.com\/th\/2026\/04\/21\/testosterone-barometer-mens-health\/pexels-enginakyurt-13088864\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?fit=8192%2C6144&amp;ssl=1\" data-orig-size=\"8192,6144\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"pexels-enginakyurt-13088864\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?fit=800%2C600&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=800%2C600&amp;ssl=1\" alt=\"Man exercising \u2014 lifestyle and fitness complement testosterone therapy for better mental health\" class=\"wp-image-9340\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?w=8192&amp;ssl=1 8192w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=1024%2C768&amp;ssl=1 1024w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=1536%2C1152&amp;ssl=1 1536w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=2048%2C1536&amp;ssl=1 2048w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=16%2C12&amp;ssl=1 16w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=1200%2C900&amp;ssl=1 1200w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=800%2C600&amp;ssl=1 800w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=600%2C450&amp;ssl=1 600w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=400%2C300&amp;ssl=1 400w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?resize=200%2C150&amp;ssl=1 200w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?w=1600&amp;ssl=1 1600w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/04\/pexels-enginakyurt-13088864.jpg?w=2400&amp;ssl=1 2400w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">The Bottom Line<\/h2>\n\n\n\n<p>While testosterone is not currently a &#8220;standard&#8221; treatment for depression, this evidence suggests it could be a powerful <strong>adjunct therapy<\/strong> (used alongside other treatments) for men struggling with their mood. Every patient is different, and Testosterone Therapy (TTh) should always be started under the guidance of a qualified urologist or men\u2019s health specialist, with proper lab testing and monitoring.<\/p>\n\n\n\n<p>If you are a man over 40 experiencing persistent low mood, fatigue, brain fog, or loss of motivation \u2014 and traditional antidepressants have not worked fully \u2014 it may be worth checking your testosterone levels. Your internal &#8220;barometer&#8221; may be telling you something important.<\/p>\n\n\n\n<p>Could your testosterone levels be the missing piece of your mental health puzzle?<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>&#8220;If you are concerned about your testosterone levels or struggling with low mood, Dr. Soarawee offers confidential consultations at Bangkok Hospital Headquarters. <a href=\"https:\/\/www.bangkokhospital.com\/en\/bangkok\/doctor\/dr-soarawee-weerasopone-2\">Book a consultation here<\/a>.&#8221;<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Q1: Can testosterone therapy really help with depression?<\/h3>\n\n\n\n<p>Yes. A 2019 meta-analysis in <em>JAMA Psychiatry<\/em> of 27 clinical trials involving nearly 1,900 men found that testosterone treatment was associated with a significant reduction in depressive symptoms. Men on testosterone were about twice as likely to experience a 50% or greater reduction in depression scores compared to placebo \u2014 results comparable to many standard antidepressants.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Q2: Do I need to have low testosterone for it to help my mood?<\/h3>\n\n\n\n<p>No. One of the most striking findings of the JAMA Psychiatry study was that the antidepressant effect did not depend on baseline testosterone levels. Both hypogonadal (clinically low testosterone) and eugonadal (normal testosterone) men experienced improvements, as did both younger and older men. However, treatment should always be individualized and monitored by a urologist.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Q3: How long does it take for testosterone therapy to improve mood?<\/h3>\n\n\n\n<p>Every patient is different, but some men in the studies began to see improvements in depressive symptoms in as little as 3 to 6 weeks. Effects were observed across various delivery methods \u2014 gels (transdermal), intramuscular injections, and oral medications \u2014 with higher doses showing stronger clinical effects.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Q4: Should I replace my antidepressant with testosterone therapy?<\/h3>\n\n\n\n<p>No. Testosterone therapy is not a replacement for standard antidepressant treatment or psychotherapy. Current evidence supports its role as an <em>adjunct<\/em> (add-on) therapy for men with persistent depressive symptoms, particularly when combined with comprehensive care. Always consult both your urologist and mental health professional before making changes to your treatment plan.<\/p>\n\n\n\n<p><strong>Medically written &amp; reviewed by:<\/strong> Dr. Soarawee Weerasopone (Dr. Pom) \u2014 Board-Certified Urologist, Bangkok Hospital Headquarters.<br>International Fellow: Baylor College of Medicine (USA) \u00b7 Juntendo University (Japan) \u00b7 Chang Gung Memorial Hospital (Taiwan).<\/p>\n\n\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Can testosterone therapy really help with depression?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes. A 2019 meta-analysis in JAMA Psychiatry of 27 clinical trials involving nearly 1,900 men found that testosterone treatment was associated with a significant reduction in depressive symptoms. Men on testosterone were about twice as likely to experience a 50% or greater reduction in depression scores compared to placebo \u2014 results comparable to many standard antidepressants.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Do I need to have low testosterone for it to help my mood?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. One of the most striking findings of the JAMA Psychiatry study was that the antidepressant effect did not depend on baseline testosterone levels. Both hypogonadal (clinically low testosterone) and eugonadal (normal testosterone) men experienced improvements, as did both younger and older men. However, treatment should always be individualized and monitored by a urologist.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How long does it take for testosterone therapy to improve mood?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Every patient is different, but some men in the studies began to see improvements in depressive symptoms in as little as 3 to 6 weeks. Effects were observed across various delivery methods \u2014 gels (transdermal), intramuscular injections, and oral medications \u2014 with higher doses showing stronger clinical effects.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Should I replace my antidepressant with testosterone therapy?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No. Testosterone therapy is not a replacement for standard antidepressant treatment or psychotherapy. Current evidence supports its role as an adjunct (add-on) therapy for men with persistent depressive symptoms, particularly when combined with comprehensive care. Always consult both your urologist and mental health professional before making changes to your treatment plan.\"\n      }\n    }\n  ]\n}\n<\/script>\n\n\n\n<p><strong>Disclaimer:<\/strong> This content is written and reviewed by Dr. Soarawee Weerasopone, a board-certified urologist at Bangkok Hospital Headquarters. It is intended for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any medical treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0e01\u0e32\u0e23\u0e27\u0e34\u0e40\u0e04\u0e23\u0e32\u0e30\u0e2b\u0e4c\u0e2d\u0e20\u0e34\u0e21\u0e32\u0e19 (meta-analysis) \u0e08\u0e32\u0e01\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23 JAMA Psychiatry \u0e1b\u0e35 2019 \u0e0b\u0e36\u0e48\u0e07\u0e23\u0e27\u0e1a\u0e23\u0e27\u0e21\u0e02\u0e49\u0e2d\u0e21\u0e39\u0e25\u0e08\u0e32\u0e01\u0e01\u0e32\u0e23\u0e17\u0e14\u0e25\u0e2d\u0e07\u0e17\u0e32\u0e07\u0e04\u0e25\u0e34\u0e19\u0e34\u0e01 27 \u0e23\u0e32\u0e22\u0e01\u0e32\u0e23 \u0e0a\u0e35\u0e49\u0e43\u0e2b\u0e49\u0e40\u0e2b\u0e47\u0e19\u0e27\u0e48\u0e32\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22\u0e2e\u0e2d\u0e23\u0e4c\u0e42\u0e21\u0e19\u0e40\u0e17\u0e2a\u0e42\u0e17\u0e2a\u0e40\u0e15\u0e2d\u0e42\u0e23\u0e19\u0e2d\u0e32\u0e08\u0e0a\u0e48\u0e27\u0e22\u0e25\u0e14\u0e2d\u0e32\u0e01\u0e32\u0e23\u0e0b\u0e36\u0e21\u0e40\u0e28\u0e23\u0e49\u0e32\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e0a\u0e32\u0e22\u0e44\u0e14\u0e49\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e21\u0e35\u0e19\u0e31\u0e22\u0e2a\u0e33\u0e04\u0e31\u0e0d \u0e41\u0e21\u0e49\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e17\u0e35\u0e48\u0e21\u0e35\u0e23\u0e30\u0e14\u0e31\u0e1a\u0e2e\u0e2d\u0e23\u0e4c\u0e42\u0e21\u0e19\u0e40\u0e17\u0e2a\u0e42\u0e17\u0e2a\u0e40\u0e15\u0e2d\u0e42\u0e23\u0e19\u0e1b\u0e01\u0e15\u0e34\u0e01\u0e47\u0e15\u0e32\u0e21 \u0e19\u0e1e. \u0e42\u0e2a\u0e23\u0e30\u0e27\u0e35 (\u0e2b\u0e21\u0e2d\u0e1b\u0e2d\u0e21) \u0e41\u0e1e\u0e17\u0e22\u0e4c\u0e1c\u0e39\u0e49\u0e40\u0e0a\u0e35\u0e48\u0e22\u0e27\u0e0a\u0e32\u0e0d\u0e14\u0e49\u0e32\u0e19\u0e23\u0e30\u0e1a\u0e1a\u0e17\u0e32\u0e07\u0e40\u0e14\u0e34\u0e19\u0e1b\u0e31\u0e2a\u0e2a\u0e32\u0e27\u0e30 \u0e42\u0e23\u0e07\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25\u0e01\u0e23\u0e38\u0e07\u0e40\u0e17\u0e1e \u0e2d\u0e18\u0e34\u0e1a\u0e32\u0e22\u0e16\u0e36\u0e07\u0e2b\u0e25\u0e31\u0e01\u0e10\u0e32\u0e19\u0e14\u0e31\u0e07\u0e01\u0e25\u0e48\u0e32\u0e27.<\/p>","protected":false},"author":185281453,"featured_media":10167,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"A 2019 JAMA Psychiatry meta-analysis suggests testosterone therapy may reduce depressive symptoms in men. 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