{"id":10175,"date":"2026-05-19T20:00:00","date_gmt":"2026-05-19T13:00:00","guid":{"rendered":"https:\/\/drsoaraweeurology.com\/?p=10175"},"modified":"2026-05-11T16:33:24","modified_gmt":"2026-05-11T09:33:24","slug":"testosterone-prostate-cancer-saturation-model","status":"publish","type":"post","link":"https:\/\/drsoaraweeurology.com\/km\/2026\/05\/19\/testosterone-prostate-cancer-saturation-model\/","title":{"rendered":"A New Perspective: Understanding Testosterone and Prostate Cancer"},"content":{"rendered":"\n<div class=\"wp-block-columns coblocks-author-columns has-background is-layout-flex wp-container-core-columns-is-layout-e269d6e6 wp-block-columns-is-layout-flex\" style=\"background-color:#8C8C971A;padding-top:2.5rem;padding-right:2.5rem;padding-bottom:2.5rem;padding-left:2.5rem\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:25%\">\n<figure class=\"wp-block-image size-full is-style-rounded\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"800\" data-attachment-id=\"7037\" data-permalink=\"https:\/\/drsoaraweeurology.com\/km\/new-photo-2024\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?fit=800%2C800&amp;ssl=1\" data-orig-size=\"800,800\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Dr. Soarawee Weerasopone \u2014 Board-Certified Urologist in Bangkok, Thailand\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Dr. Soarawee Weerasopone \u2014 Board-Certified Urologist in Bangkok, Thailand&lt;\/p&gt;\n\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?fit=800%2C800&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?resize=800%2C800&#038;ssl=1\" alt=\"Dr. Soarawee Weerasopone \u2014 Board-Certified Urologist in Bangkok, Thailand\" class=\"wp-image-7037\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?w=800&amp;ssl=1 800w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2023\/12\/New-Photo-2024.png?resize=768%2C768&amp;ssl=1 768w, 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noopener\">Bangkok hospital Headquarter, Bangkok<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.facebook.com\/DrPomUroBHQThailand\/\">Samitivej Sriracha hospital, Chonburi<\/a><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-outline is-style-outline--1\"><a class=\"wp-block-button__link has-text-color has-small-font-size has-custom-font-size wp-element-button\" href=\"https:\/\/lin.ee\/QlUAIFB\" style=\"color:#31ff00\" target=\"_blank\" rel=\"noreferrer noopener\">LINE Contact<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<ul class=\"wp-block-social-links aligncenter is-layout-flex wp-block-social-links-is-layout-flex\"><li class=\"wp-social-link wp-social-link-facebook wp-block-social-link\"><a href=\"https:\/\/www.facebook.com\/DrPomUroBHQThailand\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" 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class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M19.7,3H4.3C3.582,3,3,3.582,3,4.3v15.4C3,20.418,3.582,21,4.3,21h15.4c0.718,0,1.3-0.582,1.3-1.3V4.3 C21,3.582,20.418,3,19.7,3z M8.339,18.338H5.667v-8.59h2.672V18.338z M7.004,8.574c-0.857,0-1.549-0.694-1.549-1.548 c0-0.855,0.691-1.548,1.549-1.548c0.854,0,1.547,0.694,1.547,1.548C8.551,7.881,7.858,8.574,7.004,8.574z M18.339,18.338h-2.669 v-4.177c0-0.996-0.017-2.278-1.387-2.278c-1.389,0-1.601,1.086-1.601,2.206v4.249h-2.667v-8.59h2.559v1.174h0.037 c0.356-0.675,1.227-1.387,2.526-1.387c2.703,0,3.203,1.779,3.203,4.092V18.338z\"><\/path><\/svg><span class=\"wp-block-social-link-label screen-reader-text\">LinkedIn<\/span><\/a><\/li>\n\n<li class=\"wp-social-link wp-social-link-mail wp-block-social-link\"><a href=\"mailto:bhquro@bdms.co.th\" class=\"wp-block-social-link-anchor\"><svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\" focusable=\"false\"><path d=\"M19,5H5c-1.1,0-2,.9-2,2v10c0,1.1.9,2,2,2h14c1.1,0,2-.9,2-2V7c0-1.1-.9-2-2-2zm.5,12c0,.3-.2.5-.5.5H5c-.3,0-.5-.2-.5-.5V9.8l7.5,5.6,7.5-5.6V17zm0-9.1L12,13.6,4.5,7.9V7c0-.3.2-.5.5-.5h14c.3,0,.5.2.5.5v.9z\"><\/path><\/svg><span class=\"wp-block-social-link-label screen-reader-text\">Mail<\/span><\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">For decades, the medical community operated under a singular, frightening assumption: that <strong>testosterone is &#8220;fuel for the fire&#8221;<\/strong> when it comes to prostate cancer (PCa). If you were a man with a history of prostate cancer, testosterone therapy was strictly off the table \u2014 viewed as a dangerous catalyst that would inevitably accelerate tumor growth. However, we are now entering a &#8220;New Era&#8221; where modern evidence has challenged these long-held myths, leading to a fundamental paradigm shift in how we view men\u2019s health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">During my time working with Professor Mohit Khera at Baylor College of Medicine, I had the privilege of discussing his influential research on the <strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0302283813008439\" target=\"_blank\" rel=\"noreferrer noopener\">Saturation Model<\/a><\/strong>. This framework has revolutionized our understanding of the relationship between androgens and the prostate, providing a scientific basis for why the old fears may have been misplaced.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" width=\"800\" height=\"600\" data-attachment-id=\"10247\" data-permalink=\"https:\/\/drsoaraweeurology.com\/km\/testosterone-prostate-cancer-the-saturation-model-explained\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?fit=800%2C600&amp;ssl=1\" data-orig-size=\"800,600\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Testosterone and Prostate Cancer \u2014 The Saturation Model Explained | Visual Summary by Dr. Soarawee\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;Testosterone and Prostate Cancer \u2014 the Saturation Model explained&lt;\/p&gt;\n\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?fit=800%2C600&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?resize=800%2C600&#038;ssl=1\" alt=\"Visual summary infographic by Dr. Soarawee Weerasopone explaining the Saturation Model of testosterone and prostate cancer \u2014 showing how prostate androgen receptors saturate at low testosterone levels, why high testosterone is not a cancer risk, and why testosterone therapy may be safe for selected prostate cancer survivors\" class=\"wp-image-10247\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?w=800&amp;ssl=1 800w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer-The-Saturation-Model-Explained.jpg?resize=16%2C12&amp;ssl=1 16w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">Testosterone and Prostate Cancer \u2014 the Saturation Model explained<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">The Old Guard: The Androgen Hypothesis<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To understand where we are going, we must look at where we started. In the 1940s, researchers Huggins and Hodges observed that depriving men of androgens (through castration or estrogen) improved the condition of those with metastatic prostate cancer. Conversely, administering testosterone seemed to cause rapid progression.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">From these observations, the <strong>Androgen Hypothesis<\/strong> was born: the belief that higher testosterone promotes the development of PCa and lower testosterone is protective. For generations, medical students were taught that giving testosterone to a man with PCa was like &#8220;pouring gasoline on a fire.&#8221; This created a culture of fear \u2014 even today, an international survey showed that the risk of prostate cancer remains the primary concern for physicians considering <a href=\"https:\/\/drsoaraweeurology.com\/2026\/04\/21\/testosterone-barometer-mens-health\/\">testosterone therapy<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" width=\"800\" height=\"800\" data-attachment-id=\"10303\" data-permalink=\"https:\/\/drsoaraweeurology.com\/km\/senior-man-worried\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?fit=800%2C800&amp;ssl=1\" data-orig-size=\"800,800\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Worried Prostate Cancer Patient Denied Testosterone Therapy &amp;#8211; Old Androgen Hypothesis Era\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?fit=800%2C800&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?resize=800%2C800&#038;ssl=1\" alt=\"Worried older man with a history of prostate cancer denied testosterone therapy under the old Androgen Hypothesis \u2014 modern evidence and the Saturation Model now offer relief from hypogonadism symptoms such as fatigue, depression, and sexual dysfunction in selected PCa survivors\" class=\"wp-image-10303\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?w=800&amp;ssl=1 800w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?resize=300%2C300&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?resize=150%2C150&amp;ssl=1 150w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?resize=768%2C768&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Senior-man-worried.jpg?resize=12%2C12&amp;ssl=1 12w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">The Paradigm Shift: The Saturation Model<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The Saturation Model, championed by experts like Dr. Khera and Dr. Abraham Morgentaler, offers a more nuanced explanation of how the prostate actually interacts with hormones.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The core idea is simple: <strong>the prostate has a finite capacity to use testosterone<\/strong>. Think of it like a sponge. Once a sponge is completely soaked, adding more water doesn\u2019t make it &#8220;wetter.&#8221; Similarly, the androgen receptors (AR) in the prostate become &#8220;saturated&#8221; at relatively low levels of serum testosterone.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Key Mechanics of Saturation<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Threshold Effect:<\/strong> Prostate tissue is exquisitely sensitive to changes in testosterone at very low concentrations (the &#8220;androgen-dependent&#8221; range).<\/li>\n\n\n\n<li><strong>The Saturation Point:<\/strong> Once testosterone levels reach approximately <strong>250 ng\/dL (8 nmol\/L)<\/strong>, the receptors are fully bound.<\/li>\n\n\n\n<li><strong>Androgen Indifference:<\/strong> Beyond this saturation point, the prostate becomes indifferent to further increases in testosterone. This explains why healthy men given massive, supraphysiologic doses of testosterone do not see an increase in their Prostate-Specific Antigen (PSA) levels or prostate volume.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">This model reconciles the dual observations that while cancer is sensitive to testosterone at near-zero levels (which is why hormone deprivation therapy works), it does <em>not<\/em> continue to grow faster just because a man has high natural testosterone.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Challenging the Myths with Evidence<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">If the old hypothesis were true, men with high testosterone should have more cancer, and men with low testosterone should have less. However, the data tells the opposite story:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>High Testosterone is Not a Risk:<\/strong> Over 20 longitudinal studies have shown <strong>no relationship<\/strong> between naturally high serum testosterone and the risk of developing prostate cancer.<\/li>\n\n\n\n<li><strong>Low Testosterone is Not Protective:<\/strong> Surprisingly, many studies suggest that low testosterone is actually associated with <strong>more aggressive, higher-grade tumors<\/strong> and a worse prognosis.<\/li>\n\n\n\n<li><strong>The PSA-to-Testosterone Ratio:<\/strong> Research suggests that a high ratio of PSA to testosterone can be a better predictor of cancer risk than PSA alone, especially in men with low testosterone levels.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Clinical Implications: A New Path Forward<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The realization that testosterone does not &#8220;feed&#8221; the tumor once the saturation point is reached has opened the door for treating symptomatic men who were previously left in the dark. Men with hypogonadism (testosterone deficiency) suffer from fatigue, depression, bone density loss, and sexual dysfunction. For many of these men who have also survived prostate cancer, the lack of treatment was a significant blow to their quality of life.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Testosterone Therapy After Treatment<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Multiple small-scale studies have now followed men who received testosterone therapy after undergoing a Radical Prostatectomy (RP) or radiation therapy:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Post-Surgery:<\/strong> In one of the largest series to date, men who received testosterone therapy after surgery actually had a <strong>lower rate of biochemical recurrence (4%)<\/strong> compared to a control group (16%).<\/li>\n\n\n\n<li><strong>Post-Radiation:<\/strong> Studies on men following brachytherapy and external-beam radiation have shown similarly reassuring results, with very low or absent recurrence rates.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">The Most Bold Step: Active Surveillance<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Perhaps the most provocative area of research involves men on Active Surveillance \u2014 those with known, untreated, low-grade prostate cancer. In a study led by Dr. Morgentaler and colleagues (including Dr. Khera), 13 men on active surveillance were treated with testosterone therapy for an average of 2.5 years. The results were stunning: there was <strong>no definite cancer progression in any of the men<\/strong>, and in <strong>54% of the follow-up biopsies, no cancer was found at all<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"534\" data-attachment-id=\"10304\" data-permalink=\"https:\/\/drsoaraweeurology.com\/km\/happy-senior-couple\/\" data-orig-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?fit=1200%2C800&amp;ssl=1\" data-orig-size=\"1200,800\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;1&quot;}\" data-image-title=\"Happy Senior Couple After Testosterone Therapy and Prostate Cancer Treatment &amp;#8211; New Era of Men&amp;#8217;s Health\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?fit=800%2C534&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?resize=800%2C534&#038;ssl=1\" alt=\"Happy senior couple enjoying restored vitality, intimacy, and quality of life after testosterone therapy following prostate cancer treatment \u2014 the New Era of personalized men's health based on the Saturation Model researched by Professor Mohit Khera at Baylor College of Medicine\" class=\"wp-image-10304\" srcset=\"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?resize=1024%2C683&amp;ssl=1 1024w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?resize=300%2C200&amp;ssl=1 300w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?resize=768%2C512&amp;ssl=1 768w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?resize=18%2C12&amp;ssl=1 18w, https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Happy-senior-couple.jpg?w=1200&amp;ssl=1 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Safety and Cautionary Guidelines<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">While the &#8220;New Era&#8221; is promising, the medical community remains appropriately cautious. We still lack large-scale, long-term randomized controlled trials to guarantee absolute safety. Therefore, Dr. Khera and his colleagues recommend strict criteria before starting therapy for anyone with a history of PCa:<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><thead><tr><th>Criterion<\/th><th>Requirement<\/th><\/tr><\/thead><tbody><tr><td><strong>Diagnosis<\/strong><\/td><td>Clinical symptoms must match a diagnosis of testosterone deficiency.<\/td><\/tr><tr><td><strong>Consent<\/strong><\/td><td>The patient must understand that long-term safety data are limited.<\/td><\/tr><tr><td><strong>PSA Stability<\/strong><\/td><td>The patient should have an undetectable or stable PSA level.<\/td><\/tr><tr><td><strong>Monitoring<\/strong><\/td><td>Rigorous follow-up, especially in the first year, is mandatory.<\/td><\/tr><tr><td><strong>Exclusions<\/strong><\/td><td>Therapy is not recommended for men currently on Androgen Deprivation Therapy (ADT).<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Strict safety criteria recommended by Dr. Khera and colleagues before starting testosterone therapy in men with a history of prostate cancer.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion: The Future of Men\u2019s Health<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The shift from the Androgen Hypothesis to the Saturation Model represents one of the most significant changes in urological history. It moves us away from a &#8220;one-size-fits-all&#8221; prohibition and toward <strong>personalized medicine<\/strong>, where we can treat the whole patient rather than just a laboratory value.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Working at Baylor with Dr. Khera, it became clear that our goal is not just to extend life, but to ensure that <em>life is worth living<\/em>. By understanding that testosterone\u2019s effect on the prostate is limited by the saturation of its receptors, we can finally begin to offer relief to men who have long been told that their symptoms were a necessary price to pay for their cancer survival.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As we look toward the next 15 years, the possibility even exists that testosterone therapy might one day play a role in <strong>prophylaxis<\/strong> (prevention), as we continue to see that a healthy hormonal environment is often the best defense against aggressive disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are a prostate cancer survivor or have been told you cannot consider testosterone therapy due to PCa concerns, it may be worth seeking a second opinion based on the latest evidence. Dr. Soarawee Weerasopone offers specialist consultations in men\u2019s health and testosterone therapy at Bangkok Hospital Headquarters. <a href=\"https:\/\/www.bangkokhospital.com\/en\/bangkok\/doctor\/dr-soarawee-weerasopone-2\" target=\"_blank\" rel=\"noreferrer noopener\">Book a Consultation<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently Asked Questions About Testosterone and Prostate Cancer<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Does testosterone therapy cause prostate cancer?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Current evidence does not support the long-held belief that testosterone causes prostate cancer. Over 20 longitudinal studies have found no link between naturally high testosterone levels and PCa risk. The Saturation Model, developed by Dr. Khera and Dr. Morgentaler, explains why: prostate androgen receptors become fully saturated at relatively low testosterone levels (around 250 ng\/dL), so additional testosterone does not stimulate further growth.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is it safe to take testosterone after prostate cancer surgery?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Multiple studies suggest yes, when proper criteria are met. In one of the largest series to date, men who received testosterone therapy after radical prostatectomy had a lower rate of biochemical recurrence (4%) compared to controls (16%). However, treatment requires undetectable or stable PSA, rigorous monitoring, and shared decision-making with a urologist.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is the Saturation Model in simple terms?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Think of the prostate like a sponge. Once it is fully soaked with testosterone, adding more does not make it &#8220;wetter.&#8221; The prostate\u2019s androgen receptors become saturated at relatively low testosterone levels, so beyond that point, the prostate becomes indifferent to additional testosterone. This is why men with very high natural testosterone do not have higher prostate cancer rates.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is low testosterone protective against prostate cancer?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No \u2014 in fact, the opposite may be true. Several studies suggest that low testosterone is associated with more aggressive, higher-grade prostate tumors and a worse prognosis. The PSA-to-testosterone ratio may also be a more reliable risk indicator than PSA alone, especially in men with low testosterone levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Medically written &amp; reviewed by:<\/strong> Dr. Soarawee Weerasopone (Dr. Pom) \u2014 Board-Certified Urologist, Bangkok Hospital Headquarters.<br>International Fellow: Baylor College of Medicine (USA) \u00b7 Juntendo University (Japan) \u00b7 Chang Gung Memorial Hospital (Taiwan).<\/p>\n\n\n\n<script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Does testosterone therapy cause prostate cancer?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Current evidence does not support the long-held belief that testosterone causes prostate cancer. Over 20 longitudinal studies have found no link between naturally high testosterone levels and PCa risk. The Saturation Model, developed by Dr. Khera and Dr. Morgentaler, explains why: prostate androgen receptors become fully saturated at relatively low testosterone levels (around 250 ng\/dL), so additional testosterone does not stimulate further growth.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is it safe to take testosterone after prostate cancer surgery?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Multiple studies suggest yes, when proper criteria are met. In one of the largest series to date, men who received testosterone therapy after radical prostatectomy had a lower rate of biochemical recurrence (4%) compared to controls (16%). However, treatment requires undetectable or stable PSA, rigorous monitoring, and shared decision-making with a urologist.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is the Saturation Model in simple terms?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Think of the prostate like a sponge. Once it is fully soaked with testosterone, adding more does not make it wetter. The prostate androgen receptors become saturated at relatively low testosterone levels, so beyond that point, the prostate becomes indifferent to additional testosterone. This is why men with very high natural testosterone do not have higher prostate cancer rates.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is low testosterone protective against prostate cancer?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"No - in fact, the opposite may be true. 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Dr. Soarawee Weerasopone, urologist at Bangkok Hospital, explains the Saturation Model and what it means for men with hypogonadism and PCa history.<\/p>","protected":false},"author":185281453,"featured_media":10237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"New evidence challenges the old myth that testosterone fuels prostate cancer. Dr. Soarawee, urologist at Bangkok Hospital, explains the Saturation Model.","jetpack_seo_html_title":"Testosterone and Prostate Cancer: The Saturation Model | Dr. Pom Bangkok","jetpack_seo_noindex":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[1363],"tags":[],"class_list":["post-10175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mens-health"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/drsoaraweeurology.com\/wp-content\/uploads\/2026\/05\/Testosterone-Prostate-Cancer.jpg?fit=1200%2C630&ssl=1","jetpack_likes_enabled":false,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pgZdrK-2E7","_links":{"self":[{"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/posts\/10175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/users\/185281453"}],"replies":[{"embeddable":true,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/comments?post=10175"}],"version-history":[{"count":3,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/posts\/10175\/revisions"}],"predecessor-version":[{"id":10306,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/posts\/10175\/revisions\/10306"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/media\/10237"}],"wp:attachment":[{"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/media?parent=10175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/categories?post=10175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drsoaraweeurology.com\/km\/wp-json\/wp\/v2\/tags?post=10175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}